I have studied a series of articles which are related to increasing memory or focus.
I am going to design a mixed drug containing various supplements including DHA (Docosahexaenoic acid), Citicoline , Acetyl-l-Carnitine (ALC) , Phosphatidylserine (PS) , Vinpocetine , L-alpha-glycerylphosphorylcholine , vitamins, minerals, nanomaterials, traditional nutrients like Bacopa Monnieri , Huperzine A , Ginkgo Biloba , so on.
I need to know, is it possible to mix all (or some) of them or not?
My main aim in this study is to increase memory by different methods such as:
Increasing Blood Brain Barrier permeability to nutrients.
Increasing cell respiration of brain mitochondria.
Improving nerve cells which are damaged in Nerve-racking events.
Improving Gut Microbiota balance connecting to the gut-brain axis.
Increasing blood pressure to brain.
etc
I am looking for a motivated supervisor and researcher to start this project. Necessarily, I need your valuable comments about the project.
Is it a novel plan?
Is there any obstacle on the way of my proposal?
Can I start the animal trial on mice or rat?
Would be the drug useful for Alzheimer patients or other mental disorders?
Any helpful comments will be appreciated.
With Kind regards,
Hi, could you further clarify your question - do you mean are they physically mixable or their safety profile when combined together for administration? For the former, an oil-based formulation should work for DHA, Citicoline, PS, Vinpocetine, L-alpha-glycerylphosphorylcholine, fat-soluble vitamins (A,D,E,K) and nanomaterials (depending on their outside coat) where they will readily dissolve into the hydrophobic oil; and a powdered form for ALC, minerals, traditional nutrients etc. You can provide a ‘morning’ dose of an oil-based drug and an ‘evening’ dose of a powdered drug if you like, but bare in mind that quite a few traditional medicines have stimulating effects on the nervous system thus should be administered early on in the day e.g. Ginkgo Biloba that you have mentioned. For the latter, the safety profile for all of these drugs when combined together have not been tested, hence their safety profile and interactions are not yet known.
Is it a novel plan?
Yes, it can be a novel plan as the drugs could have an additive effect where 1+1=3.
Is there any obstacle on the way of my proposal?
Yes, in relation to the safety profiles.
Can I start the animal trial on mice or rat?
If the pills are quite bulky, then you should use rats.
If you’d like to conduct more genetic-interventions or investigate a particular disease due to a gene-alteration then I’d suggest mice. However, note that doing experiments on mice are more challenging due to their small size, especially on the surgical- and histological-side.
Would be the drug useful for Alzheimer patients or other mental disorders?
I would start with healthy animals first, then work towards disease-models.
Apart from the obvious Alzheimer's and Parkinson’s disease patients, the drug may also benefit Multiple Sclerosis and IBS patients due to the drug mechanism you have mentioned above.
Dear Prof. Karen A. Darbinyan , I would like to evaluate the possibility of the project. Honestly, I am going to start this project as my PhD thesis. You said exact answers on these questions equal to PhD defense, but I would say exact answers on some of these questions equal to PhD proposal defense :)
Dear Prof. Xiao Xiao Han ,
Firstly, I would like to appreciate you for your valuable comments and guides.
Secondly, you are right. I need to separate oil-based and powdered ingredients.
Thirdly, I am totally agree with you. This study will be physiological (Neuro-biological) research that it seems we should consider rat for animal trials, not mice.
Finally, I appreciate your time and consideration again.
Kind regards
My pleasure Jamil Kheirvari Khezerloo . Keep me posted with updates on this novel project.
Very good topic of research, carry on Doctor, best regards
Dear Muhammad Abdullah Al Mamun , Thank you.
I will do that
Kind regards,
Drugs do not increase a person's brain power. Though, a lack of proper nutrition can decrease proper organ function.
Hi @ Jamil Kheirvari Khezerloo,
You studied already too much making it hard to summarize & choose a field of interest. The topics you mentioned may be your life long works. Putting all known good items together may not produce a good result. Make a brain-storm of the causes of memory deficits, as you think or know; try to interconnect them and argue to establish one main cause. Try to solve this main cause, which will naturally solve almost all other auxiliary causes. That may suffice your Ph.D. theme. Good luck.
I agree with Tapan Kumar Mazumder , concentrate on the main research question first. When you have completed that, then move on to add embellishments. There's too many variables here, there won't be enough time for the duration of the PhD.
Hi,
It is by adopting to a healthy & smart lifestyle, that allows you a night's sleep (>7-8 hours), rejecting negatives and harboring & culturing positives, help develope a healthy brain. Good luck.
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