Hello

Some research suggests the memory cells goes under the process of apoptosis by effect in cellular pathway to induction of cell death , also the function of apoptosis in the development and function of T lymphocytes has been an exciting field for years. However, many issues remain to be addressed. For examples, what are the detailed molecular mechanisms of thymocyte apoptosis in vivo? Which molecules are essential for effector and memory T lymphocyte survival? Which molecules are involved in the contraction phase of T cell immune responses? The answers to these questions will not only further our knowledge of T cell biology, but will have great implications in vaccine design and immunotherapy as well.

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Thanks saleh sir..

Dr KUmar there are two issues you have to consider. First memory cells are cells which which could be in a normal senesence, and thus apoptosis should procede under usually extrinsic stimulation through CD95 and the other issue is hyperstimulation, eg anti CD3 (intrisic apoptosis). You can monitor both pathways using FLICA by flow cytometry.

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