Dear Hemraz,

Please have a look at this useful ResearchGate link and request the authors for feedback.

https://www.researchgate.net/publication/266951015_An_effective_method_for_improving_outcomes_in_patients_with_a_fertilization_defect

Good luck!

Thanks Arvind.

I really appreciate it. Cheers.

Please also have a look at these useful ResearchGate links.

Conference Paper Fertilization and embryo quality with and without artificial...

Article The IMSI procedure improves poor embryo development in the s...

Article The predictive value of high-magnification sperm morphology ...

Article Report of a successful ongoing pregnancy as a result of IMSI...

Article Intracytoplasmic morphologically selected sperm injection ou...

Good luck!

Dear Hemraz,

According to literature and discussions from the people who does both ICSI & IMSI routinely, What I have understood is that IMSI will slightly boost the Implantation rates and reduces the miscarriage rates.

Still large studies are needed to concluded which is the superior method.

From the theoretical point of view IMSI should give better results when compared to ICSI.

Regards,

Sanketh Dhumal S

Thanks Sanketh, your expert opinion is much valued.

You can go through the literature and will find very controversial articles on application of the IMSI on fertilisation, implantation and recurrent pregnancy losses.

Upto best of my knowledge and articles which I read, It is concluded from my end that IMSI can not improve fertilisation rate and implantation rate but IMSI is having the role in reducing the rate of RPL.

Still there is a huge scope to conduct comprehensive RCTs on larger population size to validate the data/literature.

I hope you will be satisfy with my answer.

Article Regular (ICSI) versus ultra-high magnification (IMSI) sperm ...

Results from RCTs do not support the clinical use of IMSI. There is no evidence of effect on live birth or miscarriage and the evidence that IMSI improves clinical pregnancy is of very low quality. There is no indication that IMSI increases congenital abnormalities. Further trials are necessary to improve the evidence quality before recommending IMSI in clinical practice. 2013 cochrane analysis.

IMSI is ICSI at better magnification, again time taken to search the sperm , exposure of dish out side , expertise of embryologist are the factors plays a major role. Any procedure one need to be careful while doing.

Thank you Charulata.

Hi Hemraz,

there are still controversies whether vacuoles in the sperm head is good or bad (Article Vacuoles in sperm head are not associated with head morpholo...

However it is interesting to see the the result and conduct another analysis using DNA fragmentation tools such as Halosperm or even compare it with PICSI.

Hello Hemraz,

We can't ignore importance of quality of sperm used for ICSI for its effect on fertilization, embryo development and healthy birth. Various methods are used to select the best sperm including, gradient filtration, swim up, PICSI dish, selection through PVP or any other highly viscous solution and IMSI. The defects in the sperm could be at biochemical/molecular level or at morphology level. We know that morphology alone is not a precise indicator of genetic or molecular defects. IMSI is based on viewing the sperm at more than 6000 x magnification just to identify morphological defects as compared to 400 x magnification of conventional ICSI. The outcome will depend on what kind of defects are in the sperm. For example, if sperm has high DNA fragmentation or other genetic problems, it may't be picked by IMSI. The impact of selection tool we use to pick the best sperm will depend on the underlying cause. One tool is not useful in all situations. Also there are other factors that will affect the fertilization, pregnancy, miscarriage and live birth. That is why we see contradictory outcomes. Two major concerns about IMSI are its higher cost and significantly longer time needed for injection. If some one can afford these 2, IMSI is another tool to improve sperm selection.

I have got good results with IMSI in cases with severe male factor like SOAT,OAT and Teratozoospermia cases. Both implantation and live birth rates are much better when compared with ICSI.

I have got good results with IMSI in cases with severe male factor like SOAT,OAT and Teratozoospermia cases. Both implantation and live birth rates are much better when compared with ICSI. Have done almost hundred such cases.

Dear Hemraz,

I have got good results with IMSI in cases with poor male factor like SOAT, OAT and Teratozoospermia. Both implantation and live birth rates are much better when compared to ICSI in such cases. I have now done almost 150 cases.

Dear Hemraz,

I have got good results with IMSI in cases with poor male factor like SOAT, OAT and Teratozoospermia. Both implantation and live birth rates are much better when compared to ICSI in such cases. I have now done almost 100 cases.