I have been working with ILES in OpenFOAM for numerical simulation of partial sheet cavitation. I would like a backup of your opinions about the subgrid model and subgrid dissipation.
The performance of ILES methods is strongly dependent on the numerical approach, and the grid resolution you can afford. In theory,as long as the grid resolution is sufficiently high that the large scales are unaffected by the numerical dissipation then the solution should be correct. However, for some numerical schemes and on poor grids this could be very difficult to achieve, particularly in complex flows. Note, though, that a similar problem exists in standard sub-grid modelling too, but the underlying algorithms do not typically vary as substantially as different ILES methods. So in summary - you could try ILES, but make sure that you have a strong justification for why your choice of discretisation works as an ILES algorithm.
We started with ILES in cavitating flows to avoid the explicit coupling between mass transfer modelling and subgrid modelling. But, as Ben points out, we had then worked for some time with different subgrid modelling approaches and had built our experience in performance of different models on different resolution.