Exfoliative dermatitis is a flare, a common severe for form many dermatosis like psoriasis, atopic dermatitis, pityriasis rubra pilaris etc. Cytokine load might be a major cause of that downgrading state of diseases. So, there might be any relation of cytokine surge with ED.
As for psoriasis and many other dermatoses with flare ups, would be reasonable to notice a cytokine spike. Data is too scarce to draw final conclusions, though.
Cytokine storm is an aggressive Inflammatory response with the release of large amounts of pro-inflammatory cytokines. This is a life threatening systemic Inflammatory response involving highly elevated levels of circulating cytokines with immune cell hyperactivation. All these can be triggered by pathogens,cancers,autoimmune diseases, various treatment modalities. Erythroderma/exfoliative dermatitis is a difficult to control scenarion in dermatology and demonstrates diffuse erythema and scaling of greater than 90% of the body surface area. The most common dermatologic causes like psoriasis/atopic dermatitis may cause cytokine flare-ups. The inflammation thus caused may account for its clinical picture/favorable response to systemic glucocorticoids.
- Badges
- Science method
- Similar topics
- Mathematics
- Statistics
- Statistical Modeling
- Analyses of Variance
- ANOVA