If I would like to know whether alternative splicing occur in some gene, What bioinformatics tool can answer my question?

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Salma H. El Aksher

This depends on, if the gene has different isoforms to encoded to different proteins.

maybe this site helped you

http://www.expasy.org/genomics

Manvendra Singh

please elaborate your question

Alternate splicing is highly cell type and species specific event

if you want to check if genes have known isoforms then have a look at ucsc genome browser