I was looking into a study on the inhibition of atherosclerosis in diabetic pigs using anti alphavbeta3 antibody. I just wanted to know...
Is it possible that integrin alphavbeta3 could be replaced by another integrin when antagonised with an antivbeta3 antibody? for example alphavbeta1
Is inducing diabetes with streptozotocin a bad idea..for example Is it possible that using such a drug could have an effect on atherosclerotic lesion...I found that SIRT1 is increasingly expressed following the use of streptozotocin which has been found to exhibit anti-aging effects.
What would be the most appropriate controls to use for such a study.
would an IgG F(ab)2 antibody be appropriate or are there better controls to utilise?
Any help would be greatly appreciated..Please see the paper I am referring to in the link attached...
Hi Jonathan, avb3 is an integrin that can bind to RGD sequences directly no matter where they are exposed. The other major integrin that shares this is avb5.
You should be careful about the inhibitory specificity of the antibody you are using. The b3 integrin subunit is also the major integrin on platelets (gpIIab3).
Inhibiting platelet integrins can have many vascular implications.
Hi Jonathan i have send u a message on your watts app, let me know mate thanks
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