I am working on the synthesis of coumarin derivatives with aldehyde functionality by condensing a hydroxyaldehyde and 𝛽-ketoester using Pechmann condensation reaction. I need your responses esteemed co-researchers.
If you could protect the aldehyde end and keep it stable during acidic condensation! The beta keto esters are better and direct choice. Why don't you work on that part and subsequently follow the normal/ideal reaction.
Dear Chisom Friday thank you for asking this very interesting technical question. As an inorganic chemist I'm not a proven expert in the field of organic synthesis. To the best of my knowledge, the synthesis of this coumarin derivative using Pechmann condensation reaction should be possible. A good overview has been provided in the attached review article entitled "One-Pot Synthesis of Coumarin Derivatives". Normally the Pechmann reaction requires the use of an acidic catalyst. Also please find attached the Open Access review article "Recent Advances in the Synthesis of Coumarin Derivatives from Different Starting Materials". I hope it helps. Good luck with your work!
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