I want to reduce amidic carbonyl group to methylene only in a compound which contains both amide and acetyl groups?
If I get it correctly, you want to reduce an amide to hydrocarbon selectively in the presence of an acetyl group?
If this is correct, I think it is very difficult and substrate dependent.
1, It is possible to selectively reduce certain amides to amines in the presence of an ester
http://www.organic-chemistry.org/synthesis/C1H/reductionamides.shtm some references are provided here at OrgChem portal.
2. To reduce the amide directly to the hydrocarbon has been reported before with specific substrate scope
http://pubs.acs.org/doi/abs/10.1021/acscatal.6b03040
To reduce an amide or amine more generally, it will likely need to go through a ketone/aldehyde or alcohol intermediate, without more details I don't think it is likely for the acetyl group to survive so many steps.
Mohammed
To the best of my knowledge to perform such transformation you should
1-protect your acetyl group as ketal
2- reduce the amide , see
--- Bailey, Christopher L.; Joh, Alexander Y.; Hurley, Zefan Q.; Anderson, Christopher L.; Singaram, Bakthan, Journal of Organic Chemistry (2016), 81(9), 3619-3628
3- de-protect your carbonyl
Good luck
good answer Adel Amer
Dear prof, Adel
I appreciate your prompt and useful reply
thanks and regards
The hydrophobic tail connected to peptide via urea bond. I tried 0.1% TFA in ACN, 0.1% TFA, DMSO, and methanol but it still insoluble.
07 August 2018 2,389 0 View
(conversion of pyrimidine-2-carbonitrile derivative to pyrimidine-2-carboximidamide)
10 November 2016 1,384 13 View
Approximate concentrations are require in compared with the WHO permissible limts
11 August 2024 2,723 1 View
Hey there, As a synthetic chemist delving into theoretical calculations for my imidazolium-based organic molecules, I would greatly appreciate any guidance on the appropriate input instructions...
09 August 2024 5,444 7 View
I'm currently working on calculating the collision cross section (CCS) for various ions, and I'm facing challenges when dealing with sodiated and multiply charged ions. Most of the resources I’ve...
08 August 2024 8,329 0 View
Hello What should be done to separate and identify organic acids in HPC when their RetTime is the same?Like oxalic acid with Propanoic Acid.or acids that have a very close RetTime.
07 August 2024 8,782 3 View
I used humic acid at 0.044 g/kg soil in my pot experiment. But finally, I have to recommend kg/ha. Each pot's soil weight was 11 kg. What is the solution?
02 August 2024 7,186 6 View
Hello! I have this scale which had 10 items initially. I had to remove items 8 and 10 because they correlated negatively with the scale, and then I removed item 9 because Cronbach's alpha and...
01 August 2024 4,606 7 View
Just bounced on me. Before statistically analysing significant difference, shouldn't we see if data fits normal distribution first? Is 3 replicates enough to testify the hypothesis of normal...
31 July 2024 8,141 13 View
Does anyone know of a module for the JAMOVI software that is capable of generating mean separations using the classic letters based on post hoc results (e.g., Tukey test)? If, as I believe, such...
31 July 2024 3,333 4 View
Hi everyone, I'd like to better separate two close peaks coming from a bioconversion sample, I'm currently using a C18 KromaPhase 4,6mm Ø.I. SCHARLAU, particle size (µm): 10, pore size (Å): 100,...
30 July 2024 435 3 View
I am currently working on a project involving liposomes and need to determine the maximum volume of siRNA that can be added to a 2.5 mL liposome solution with a total lipid concentration of 10...
30 July 2024 6,420 1 View