Dear Shweta Jindal, I suggest to your attention the paper regarding the general principles of using metamaterials for antennas
Conference Paper Metamaterials on antenna solutions
In any case, designing a metamaterial unit cell will be dependent on an antenna design. As an example, for the patch antenna metamaterials unit cells can be used inside substrate or around the patch or as frequency selective surface (lens). Up to you.
Usually the resonant frequency of the metamaterial unit cell is selected same as that of patch antenna. However it must consider the parameters like pass band, stop band, miniaturization factor etc. For gain enhancement applications you can use High Impedance Surfaces. Software optimization also helps to arrive at optimum dimensions.