I am working on a pharmacological problem. The efficacy of curcumin in reversing diabetes was recently shown by Rashid and Sil, 2015 where they showed complete pancreas recovery. But like others have suggested, the intestine is believed to play a role in mediating curcumin effects since plasma exposure is low. I want to replicate part of these works and add some novel insight. but i just bought curcumin which is 67% and realized there is also a 94%. can i proceed and would such work be valid and recognized by peer-reviewed journals
The problem with using a low-purity reagent, in general, is the difficulty it creates for ascribing any observed effect to the substance in question. The greater the level of purity, the more likely the effect is due to the major component rather than a minor impurity. My recommendation would be either to obtain the higher purity reagent, or purify the one you have already.
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