My jaw hits the floor. Better yet trying to convince someone when they say "Oxygen is not important in my work" I've bit my tongue for far too long and I've stayed out of the discussion.
Sure we know everything plays a role in cell biology, gravity, gas, pressure, nutrients etc.. BUT in my opinion nothing more so than Oxygen.
Oxygen homeostasis/redox homeostasis is the cellular brain IMO. Every piece of data suggests that HIF and the master hypoxamir mir-210 plays a role in most disease especially cancer. Sure some diseases like ALS and Alzheimers have other targets which is fine for identifying markers. Copper & IRON dysregulation +ROS in Alzheimers & copper and zinc homeostasis +ROS in ALS. Many people are aware of mir210, HIF and Dicer with cancer?
In my off the wall, non phd-level opinion, dysregulation of everything non-familial starts at the top, possibly with Oxygen. Ensure homeostasis as much as possible and quench the ROS with c60 like carbon nano-materials and other soon to be created mega antioxidants and life will some day be lengthened considerably.
Outside of science fiction or what I like to call the not-to-distant future; can we all please consider the possibility of more consistent data derived from employing physiologic cell culture? Can we try making progress using the readily available tools and avoid using cells which have extreme cellular damage from high oxygen? The proteins and lipids have been shown to behave in a much different way after they are exposed to higher levels of ROS. Is it time we consider we may be wasting millions of dollars producing and attempting to replicate data that may be faulty?