Most analysis relates to the effects of poor nutrition and not to energy deficit, even with normal nutrition, but below energy requirements. I intend to apply this to estimates of mortality under slavery.
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I guess that there is a need to define 'energy deficit' from 'healthy calorie restriction? the latter may be good for health and longevity provided that lower energy intake is not accompanied by nutrient deficiency. in late life, the picture would be expected to be complex...
When considering a situation of slavery, nutrient deficiency is probably a "fact of life". I see something like a general depletion of all types of body reserves. The slave would keep on going, even when receiving less energy than needed, until his body starts to fail somewhere, which would mean contracting an infection or any other disease. As his is already too weak, almost any disease becomes mortal. We are speaking here of a life-expectation of 10 to 15 years for a slave in his early 20s.
I would like to model this energy (in)balance so that it could be somehow linked to a mortality schedule.
Energy restriction impairs natural killer cell function and increases the severity of influenza infection in young adult male C57BL/6 mice. J Nutr 2008;138:2269-75.
Thanks Thomas. As I intend to model energy deficit x mortality within a demographic and economic context, I suppose that the various specific illnesses caused by lack of sufficient nutrition will need to be evaluated from/joined into some aggregate "deficiency" which in its turn affects mortality.