We regularly use Gcamp6s in our lab for in vivo calcium imaging. The problem is that we have a mouse line with GFP marking a specific cell population that we want to image in vivo and hence we need a different coloured GECI.

Specifically, I want to know if the Douglas Kim lab Rcamp indicators are sensitive enough to use in 1 photon recordings. Further, how well do they compared to Gcamp's such as Gcamp6.