I'm interested in learning how lumefantrine was actually discovered as an antimalarial agent through the famous Project 523. I'm specifically interested in:

1) What drug class was being tested and why that particular class of synthetic compounds?

2) How was it tested for antimalarial activity? Was it screened with P. berghei like artemisinin was through the same project?

3) Any references regarding the questions is also greatly appreciated!

Thank you!