Mucous will certainly hinder the uptake of the particles intranasally. How do we test the efficacy of our nanoparticles in such conditions?
Please check this article:
Bioadhesive chitosan nanoparticles: Preparation and characterization
Carbohydrate Polymers, Volume 81, Issue 2, 11 June 2010, Pages 243-251
Anitha R. Dudhani, Shantha L. Kosaraju
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