What are the conditions that favor the synthesis of triazole from hydrazone and nitrile?
It depends on which triazole you are looking for.
You can try with these article / patents
1. http://journals.tubitak.gov.tr/chem/issues/kim-02-26-5/kim-26-5-20-0201-18.pdf
2. US patent US2009009348
3. US patent 8618285
4. US patent 3910895
5. WO/2006/087077
hope this may give some direction for further literature search.
This is a common "click reaction". Maybe you can find something also with this topic.
Check for this publication in Inorganic Chemistry by Fritz Kühn and Wolfgang Herrmann from 2013
DOI: 10.1021/ic400533u
click chemistry: http://www.organic-chemistry.org/synthesis/heterocycles/1,2,3-triazoles.shtm go through this link.
its reaction between alkyne and sodium azide in presence of Cu cat.
the success of your reaction will depend on the substitution pattern, i.e., on the R and R you will have
The conditions that favor the synthesis of triazole from hydrazone and nitrile using acetonitrile solvent & triethyl amine as a base catalyst. You need C=N.NH2 group & CN group in the same compd. Intramolecular cyclization is possible. Amino group reacts with CN group to give triazole.
Hi,
There is a review about the various synthetic strategies for the synthesis of triazoles.
http://www.eurekaselect.com/108209/article
You may refer these
DOI: 10.1007/7081_2014_125
https://doi.org/10.1016/j.tetlet.2015.03.136
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