I need to determine whether climatic data from two geographical location are similar or not, and explore the relation between this difference and the occurrence of particular disease in one location than the other in the framework of ecological research. My data are time-series of 3 year of historical climatic information from those locations (4 locations with a latitude gradient). Now I compared the with paired t-test, but I feel like this is not the suitable test to use. And, this test will not actually give me seasonality of data or give the relation between some events (occurrence of outbreak) and a peak of temperature or drought for example. I use SPSS and Matlab. Is there any routine to solve this issue?