Greetings,
I wish to react TBD (Triazabicyclodecene) with a methylated polysaccharide. The method is inspired from another protocol, where the product is retrieved by precipitation.
My product however, cannot be precipitated. The reaction will most likely take place in DMF, and afterward I wish to separate excess TBD from the product.
I read TBD is soluble in water and organic solvents, which might complicate separation by liq/liq extraction. I suppose that adding dilute acid might shift TBD's preference toward water, but can not find much information about this.
Any ideas or methods from fellow chemists would be greatly appreciated.
Thank you in advance !
Do you have to use liquid-liquid distillation? If not, first remove the DMF by vacuum distillation then a simple extraction with aq 2M HCl and a suitable organic solvent for your compound.......if it is not water soluble. In theory, after removing the DMF you can treat the residue with a suitable solvent that dissolves the TBD (perhaps hexane or toluene?) but not your compound...then filtration with the same solvent wash....
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