Dear Deepak,

Long-circulating nanoparticles made of methoxypoly(ethylene glycol)- polylactide or poly(lactide-co-glycolide) (mPEG-PLA/PLGA) have a good safety profiles and provide drug-sustained release. The availability of functionalized PEG-PLA permits to prepare target-specific nanoparticles by conjugation of cell surface ligand. Using peptidomimetic antibodies to BBB transcytosis receptor, brain-targeted pegylated immunonanoparticles can now be synthesized that should make possible the delivery of entrapped actives into the brain parenchyma without inducing BBB permeability alteration. 

For a review article on this topic, please see the following link:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC539329/

A recent review article discusses a modification of the nanoparticle surface with specific brain targeting ligands or by coating with certain surfactants for enhanced brain delivery along with the mechanisms of the nanoparticle-mediated drug transport across the BBB may be helpful as well:

http://www.ncbi.nlm.nih.gov/pubmed/26845323

Hoping this will be helpful,

Rafik

Respected Rafik Karama, thanks for your help and kindness

This artcle may help you.

See overexpression of any receptors like glucosamine, transferrin, IGF 1 or 2 in the BBB... 

EGFR, transferrin, lectin,folate

I am working on Pgp receptor which is imp for over expression of most anticancer drugs