I am doing a reaction and the solvent was nitrobenzene, after the organic compound is extracted by ethyl acetate, then ethyl acetate was evaporated by rotovap but how can I evaporate the nitrobenzene to get the molecule?
Hi
Here are the possible solutions
1. A lot would depend on the boiling point of your compound of interest. You could try fractional distillation to distill your compound preferentially over nitrobenzene or maybe try vacuum distillation if the BP of your compound is way higher than that of NB (210 C).
2. If your compound of interest can tolerate the conditions, then you could try to reduce the NB to amino hydrochloride salt and extract to leave it in water.
3. Also, if your compound of interest is solid, crystallization would serve the purpose. Traces of NB should go away during vacuum drying in the oven later. If you would share the type of molecule (str etc), I could help you design the crystallization exp (like solvents etc.)
If your product does not dissolve in hexane or ether, maybe try to add hexane or ether to preciptate the product out.
If your product is polar than nitrobenzene, you may load the whole rx mixture on the top of silica gel column, nitrbenze will come out first as solvent.
Good luck!
dissolve your compound in DCM and filter, then dry the filtrate and give a wash with n-hexane. most of your impure substances and inorganic wastes will be washed out. Check for the TLC and if necessary run the column.
Guobing Xiang I did something similar, My molecule has a carboxylic acid function group so I added water then made the medium basic to let AlCl3 ppt as a Al(OH)3, then added the ether, now I know that my molecule will be in the aqueous phase and nitrobenzene will be in the ether (FYI, Ether + nitrobenzene has an almond smell and it's very similar to the smell of cyanide), finally made the medium slightly acidic and did the extraction using EtOAc
Sunil Bansal Thank you so much for your answer, I agree with you but unfortunately, all of them are depending on the physical and chemical property of the molecule, and this molecule is new so I do not know much information about it
Ganesh Prasad Shenoy Thank you very much for your reply but all the medium is liquid, the molecule is already dissolved in nitrobenzene
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