Hi Ludovica,

To overcome your problem, you can try microparticle-enhanced cultivation technology. That is a simple solution. For this, you can use talc or magnesium silicate, aluminum oxide, and titanate. Titanate is also expensive. I suggest you the following papers. However, you can find more articles regarding this topic.

I hope these articles can solve your problem.

Good luck.

Karahalil, E., Demirel, F., Evcan, E., Germeç, M., Tari, C., & Turhan, I. (2017). Microparticle-enhanced polygalacturonase production by wild type Aspergillus sojae. 3 Biotech, 7(6), 1-9.

Yatmaz, E., Karahalil, E., Germec, M., Ilgin, M., & Turhan, I. (2016). Controlling filamentous fungi morphology with microparticles to enhanced β-mannanase production. Bioprocess and biosystems engineering, 39(9), 1391-1399.

Yatmaz, E., Germec, M., Karahalil, E., & Turhan, I. (2020). Enhancing β-mannanase production by controlling fungal morphology in the bioreactor with microparticle addition. Food and Bioproducts Processing, 121, 123-130.

Gürler, H. N., Erkan, S. B., Ozcan, A., Yılmazer, C., Karahalil, E., Germec, M., ... & Turhan, I. (2021). Scale‐up processing with different microparticle agent for β‐mannanase production in a large‐scale stirred tank bioreactor. Journal of Food Processing and Preservation, 45(8), e14915.

Germec, M., Yatmaz, E., Karahalil, E., & Turhan, I. (2017). Effect of different fermentation strategies on β-mannanase production in fed-batch bioreactor system. 3 Biotech, 7(1), 77.

Karahalil, E., Coban, H. B., & Turhan, I. (2019). A current approach to the control of filamentous fungal growth in media: microparticle enhanced cultivation technique. Critical reviews in biotechnology, 39(2), 192-201.