Dear Ramsha Malik many thanks for posting this interesting technical question on RG. Personally I'm absolutely not an expert in this field as we are working in inorganic chemistry. However, I can suggest to you the following potentially useful articles which might help you in your analysis:
Determining Particle Size of Polymeric Micelles in Thermothickening Aqueous Solutions
https://bearworks.missouristate.edu/cgi/viewcontent.cgi?article=4504&context=theses
This is a Master's Thesis which is freely accessible as public full text on the internet (please see attached pdf file).
Control of Particle Size in the Self-Assembly of Amphiphilic Statistical Copolymers
Article Control of Particle Size in the Self-Assembly of Amphiphilic...
This paper has been posted by the authors as public full text on RG, so that you can freely download it as pdf file. The same is true for the following research article:
pH-sensitive micelles self-assembled from polymer brush (PAE-g-cholesterol)-b-PEG-b-(PAE-g-cholesterol) for anticancer drug delivery and controlled release
Article pH-sensitive micelles self-assembled from polymer brush (PAE...
As you can see, the "Publications" section of RG is a highly valuable source of information.
Good luck with your work and best wishes, Frank Edelmann
Dear all, the size of self assembled polymeric nanomicelles depends essentially on the length of the hydrophobic (apolar) segments of the basic copolymer, as it is the part responsible of the self assembly process. For example, in PEG-PLA diblock copolymers, the size of PNP's increases or decreases directly with that of the length of PLA. In addition to that, the nature of the encapsulated drug and the preparation procedure also contribute to the final size of PNP's. My Regards
Dear Ramsha Malik,
The hydrodynamic radius of self-assembled colloids depends essentially on the size of associated molecules and the solvated state (solvent, temperature, ionic strength...) of these monomers. Dear all, the hydrodynamic radius of self-assembled colloids depends essentially on the size of associated molecules and the solvated state (solvent, temperature, ionic strength...) of these monomers. So, the easiest way to reduce the average diameter is to reduce the size of the molecules that make up the “particles”.
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