One of the many global pressures threatening our world today is bacteria's resistance to antibiotics. Not too long after penicillin-the world's first ever antibiotic-doctors noticed an uptick in resistance of certain bacteria to penicillin. Scientists were quick to engineer new antibiotics and did so for decades at a rate quick enough to combat harmful Bacteria. Most all of these antibiotics themselves were extracted from bacteria, a solution made possible by the fact that bacteria have an antimicrobial resistome. Now there are superbugs resistant to a whole spectrum of antibiotics and the rate we produce antibiotics has decreased substantially since the latter half of the 20th century. Many reports over the last few years indicate that this is a global threat that could one day prove disastrous to humanity. Scientists have come up with possible theories and floated ideas about how to combat this issue. They include finding the gene(s) related to antibiotic resistance and blocking/inhibiting the bacteria's response to antibiotics, finding newer and stronger antibiotics, and more community practices including no sharing/overusing antibiotics. The first two are worrisome in that 1. inhibiting the gene related to antibiotic resistance may overpopulate weaker and weaker bacteria, effectively decimating bacteria (the opposite of what's happening now) and 2. Engineering another antibiotic is just going to make the problem worse. How do we go about solving this problem? Note: This is meant to be an unconstrained and open question to a broad audience. The purpose is to get a survey of ideas and perspectives from many individuals, to determine both solutions and consequences of solutions to combat this problem, and to work towards a positive goal focused on trying to tackle one of many problems that exist in a world expanding beyond its limits.
The one thing that distinguishes bacteria from many other organisms is its ability to transfer DNA through simple contact. In a closed environment one can test how modifications to the DNA of certain bacteria are passed to other bacteria and if that change permeates a closed and controlled system. Over long times we can get a sense of how this change effects the bacteria in question altogether, whether negatively or positively. It would be interesting if someone could also genetically alter bacteria so to attract other bacteria to increase the spread, although I don't specifically know what attracts bacteria other than warmth or sweat. This still has the repercussions of the first point mentioned in the initial statement in that weakening bacteria may lead to further weakening. It would be interesting if there was a way to engineer bacteria to recognize a way to switch those genes back on after a certain weakening was reached so to calibrate the bacteria back to levels reached before the antibiotic era. This, of course, is beyond my level expertise but is an interesting topic to discuss as a curious scientist. All constructive comments and ideas are welcomed. This problem may be difficult but that should never dissuade us from discussing it.
We can use bacteriophage for killing bacteria or use inhibitor (like boron)for MDR bacteria
IPC (infection prevention and control) program development and implementation will strongly help in this situations the world is facing.
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