How to recrystallization amine compound and it is not soluble in common organic solvents ?
For recrystallization of amines (as well as other basic compounds like pyridines, thiazoles etc) you may use organic acids - in particular acetic acid and its mixtures with other solvents. Also, low-boiling CF3COOH is also good solvent for basic compounds. These combinations sometimes give adducts but only rarely they form salts.
Hi Mohit Redhu The answer to this question can be very broad. But the first and the most important question to ask is , whether this amine compound hydrophobic or hydrophillic?
Also it will be very easy if you can convert this amine to its ammonium salt if it is not going to be a hazel for your further continuation.
Did you tried to dissolve it in the less amount of a polar solvent and then add to it a solution of HCl in diethyl ether? Otherwise, you could add some drops of TFA and then cold ether to the acidified solution. If you selected water at the beginning as your solvent, make sure that before adding the ether the solution pH is nearly 0. You may be lucky following this!
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