I synthesized a series of tri-substituted imidazole derivatives. But the problem is percentage yield along with the impurities. So, how I can purify the compounds with a good yield without these two techniques. I tried the TLC with the solvent system (Benzene:Acetone, 8:2, v/v) and for column chromatography, I prewashed the column with DCM and methanol and then I used 5% w/w methanolic ammonia solution.
Hi.
If don't provide more info about the compound/mixture, it's impossible for anyone to help you.
Cheers
If your compound is crystalline in nature then you can crystallize it. But, you have try the different solvent combinations for the effective crystallization.
Can you elaborate your question further. It does not tell about the media(medium) you used to synthesize your compounds.
Also, how do you know whether the rest are impurities? They could be other possible derivatives, or unreacted reagent. Did you do any preliminary tests?
Try Trituration method also besides Crystalization.
Trituration is a process used to purify crude chemical compounds containing soluble impurities. A solvent is chosen in which the desired product is insoluble and the undesired by-products are very soluble or vice versa.
The crude material is washed with the solvent and filtered, leaving the purified product in solid form and any impurities in solution.
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