An impurity formation observed up on storage of mPEG DBCO. Can any one suggest additives to make it stable...also best reaction conditions for preparation of DBCO mPEG from DBCO NHS and mPEG amine
Store at -20°C; Desiccate; Avoid frequent thaw and freeze.
addition of a slight excess of (MeCN)4CuBF4 quantitatively formed an isolable octyne–Cu complex that is unreactive towards free azides. The Cu–alkyne complex could be disrupted by the addition of aqueous ammonia, regenerating the cyclooctyne and making it available for strain-promoted azide–alkyne cycloaddition.