Hello !

I want to perform bone marrow transplantation on mice. First of all I want a total ablation of the BM of the recipient. I plan to achieve this using irradiation. I want to preserve the BBB of the mice because I don't want any BM transplanted cells to invade the brain. I was wondering if the mice's heads are outside the irradiation area the BBB will stay intact ?? Does anybody have experience with this ? I don't really want to use a headshield because I would like to irradiate several mice at the same time in a "3D-printed cage" where all the body is irradiated except the head which is outside the box....

Thank you for your help !