I'm exploring bone sample preparation methodologies. What tools and techniques safeguard bone structure and mechanical characteristics during the process? I'm also interested in shaping bones into cylindrical or cubic forms for further analysis. Any insights or experiences you can share would be immensely valuable.
Literature says that glycerol–preservation of bone yields a material that maintains biomechanical strength while eliminating the need for extensive rehydration or thaw periods if used clinically. Additionally, in vivo evidence suggests no negative impact of glycerol-preservation on the ability of bone grafts to successfully participate in new bone formation and fusion.
I presume you know that these are two questions with totally different answers.
The first question (how to preserve ...) also can be defined in different aspects (temperature, wet or dried, environmental, PH, etc). I suggest reading a reference book named "Mechanical Testing of Bone and the Bone-Implant Interface".
Regarding the second question (prepare in cylindrical or cubic shape...), have you read about a device named "Microtome". It is like a lathe machine. Normally researchers use this device (not very complicated) for preparing the desired shape.
Good Luck
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