I have been reading the article entitled, "Some Statistical Techniques for Bio-Efficacy Trials" (http://www.iasri.res.in/ebook/ebadat/6-Other%20Useful%20Techniques/6-Statistical%20Methods%20in%20Bioefficicacy%20Trials.pdf).
I am conducting a mortality trial with a non-uniform population. It appears that the Sun-Shepherd formula is best suited for corrected efficacy. I would be very grateful for feedback concerning the controls:
1. As we are normalizing to the controls, do I normalize the controls with the formula? Or do I leave the controls as is when conducting statistical comparisons? 2. When determining the value of the controls do I use the average of the controls or do I randomly select a control value?
Dear Thomson M. Paris,
I suggest you to see links and attached files in subject.
-The Impact of Tumor Biology on Cancer Treatment and ...
https://books.google.dz/books?isbn=3540743863
-Advances in Biology and Treatment of Glioblastoma
https://books.google.dz/books?isbn=3319568205
-Principles of Bone Biology
https://books.google.dz/books?isbn=0080568750
-Holland-Frei Cancer Medicine 8
https://books.google.dz/books?isbn=1607950146
-Biology of Bile Acids in Health and Disease
https://books.google.dz/books?isbn=0792387686
-Abeloff's Clinical Oncology E-Book
https://books.google.dz/books?isbn=1437720560
Best regards
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