Dear Sir. Concerning your issue about how to increase the stability of gelatin in water. The increased thermal stability and reduced water solubility of gelatin-sugar dispersions cross-linked by UV exposure. By increasing the melting temperature of gelatin, we have removed a major impediment for use of gelatin in tissue engineering applications. Since increased cross-link density generally correlates with increased mechanical strength and resistance to enzymatic degradation, it is also proposed that the described methodology enhances gelatin’s ability to serve as a material for cell scaffold applications. The method of cross-link formation is posited to require the generation of free radicals and the formation of dityrosine between neighboring molecules. Future work will investigate whether a causal link between tyrosine content and cross-link formation exists. Through selective UV irradiation of gelatin-sugar dispersions, it should be possible to synthesize physiologically benign cell scaffolds with complex geometries for tissue engineering and possibly organ growth. I think the following below link and the attached file may help you in your analysis: