I am having consistent problems with mass accuracy on the Orbitrap Fusion (see attached powerpoint). The LC is fine and so is the standard. There is some sensitivity issues but that does not explain the +10 ppm mass drift (ppm centered at 15 ~ppm) nor does it explain why this is not a problem for anyone else in the lab (they all get within +/- 10 ppm). The instrument is tuned and calibrated ~ every 3wks so this plus the fact that others are getting good mass accuracy does not explain my problem. I have also rebuilt my methods from scratch in case they were corrupted, but the results are still the same. 

Help.

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