Will it be possible to get IC:50 if we target cancer cell line with antibody drug conjugate (ADC) that have 50% less antigen positive cells ?

Is it possible to attain IC50 if my target cells have less than 50% antigen expression ? For example: Cancer cell line XXX is showing 35% of expression of cell surface antigen YYYY, if i...

04 February 2021 2,711 3 View

How to give noncollinear magnetism terms in INCAR for Double helical magnetic ordering in VASP?

Usually, the magnetic moments of noncollinear tags in the INCAR file look like MAGMOM = 0.0 1.0 0.0 if the atom has 1 unit of the magnetic moment along the b axis. But if we consider the magnetic...

19 November 2020 8,061 3 View

What will be the impact on Socio-Economic activities of man after the end of COVID-19 Pandemic?

I am very much thankful of the experts, researcher, and thinkers for very thought full discussion on my previous question on Role of Geography on COVID-19 Pandemic. Now I am keeping another very...

19 October 2020 6,552 4 View

Can someone let me know the best SiRNA along with negative controls for silencing NEAT1 in human breast cancer cells. Company and price if possible?

SiRNA for NEAT1 knockdown in breast cancer cells

05 October 2020 9,723 1 View

I would like some guidance for my project on RECLAMATION OF CONSTRUCTION MATERIALS FROM INDUSTRIAL SLUDGE?

I request the professionals in this to please help me in my project which i am doing in my final year. I'd be very grateful even if its just a bunch of research papers or websites that your...

27 August 2020 3,863 2 View

I am keeping the Question for discussion, What is the role of Geography in the study of COVID-1 pandamic?

Please give your opinion and suggestions

10 August 2020 3,990 19 View

What is the likely impact of AI on future jobs across all sectors?

We have been witnessing the advent of AI and its rapid proliferation as an intelligent machine in many applications from driverless cars, and much more. How is the lifestyle going to change as a...

05 May 2020 4,787 41 View

What is the inference from the delocalization of P-orbital?

I have attached an image. Can you kindly explain what does it mean from the delocalization of P-orbital from the LUMO plot? I have made a statement " From the LUMO plot it is seen that the...

30 March 2020 9,796 3 View

What is fermi energy of the material?

Hi all Greetings. I have calculated the fermi energy of material from HOMO-LUMO levels obtained from gaussian results. HOMO (eV) LUMO (eV) ENERGY GAP (eV) FERMI ENERGY...

23 February 2020 1,830 4 View

I need a help for explain example TLBO algorithm for feature selection with code ?

Disease dataset feature selection using TLBO algorithm code before classification of dataset

23 February 2020 2,991 3 View

Dear all, I was wondering if anyone knows whether MGLtools and Autodock can run on Mac OS?

I have tried to download the 64-bit version of MGLtools however, as many times as I have downloaded and uninstall the programs, an error arises that the app needs to be updated. Thank you.

03 March 2021 5,997 2 View

I got 02 moderator values defining Johnson-Neyman significance regions. Is it an error?

Hi everyone, I am conducting research for my Master's thesis. I am using PROCESS by Johnson-Neyman to analyze my Moderator model. I test the relationship between Public Service Motivation and...

03 March 2021 2,350 2 View

Do I need to do linear regression before running mediation analysis using PROCESS MACRO by Hayes ?

I just wanted to check if I need to run a linear regression separately if I am using PROCESS MACRO to run mediation analysis. Thank you.

02 March 2021 4,359 3 View

Do I need to strip the PVDF membrane before staining it with colloidal gold?

Dear Colleagues, After running Western blot on PVDF membrane and detection using ECL, I would like to stain my PVDF with colloidal gold to be able to allign the ECL image with total proteins on...

02 March 2021 7,829 3 View

PACYC PCR not working after several attempts. Would anyone have any suggestions?

So, I have been trying to run a pACYC PCR which will be used later on for a Gibson Assembly. However the PCR is not working. I have already tried gradient PCR and changing extension time; however...

02 March 2021 1,146 2 View

What SPSS analysis should I run with one IV (with two levels) and two DVs?

Hi, I am trying to figure out which test would be most appropriate to run for the following question: Is there a difference in task blood pressure between smokers and non-smokers? There are two...

01 March 2021 8,235 2 View

OpenBCI eeg--has anyone used them?

I'm looking to try out an off-the-shelf EEG set for some exploratory work. Curious if anyone has used the OpenBCI, and how much set-up work is required. I've heard they are more difficult to get...

01 March 2021 4,128 3 View

Is there any expert in Smart PLS who can help me?

Dear colleagues, I have a manuscript that needs an expert in smart PLS to run the analysis, Is there anyone expert and ready to help me, please?

01 March 2021 8,212 3 View

Why initial concentration of Pb not the same as calculated one when testing using AAS?

I am currently doing research on the adsorption of heavy metal using magnetic reduce graphene oxide. I use AAS to determine the concentration of the heavy metal. I prepare the Pb solution with...

26 February 2021 9,580 4 View

How to run Cross-lagged panel Design on AMOS?

25 February 2021 3,126 1 View