Hi ResearchGate Community,

I want to modify my synthetic peptide with N-terminal mesylation (i.e., the methanesulfonyl or mesyl group, Ms - CH3SO2) on a resin after final coupling. How can I achieve this N-terminal mesylation on peptide resin? Using methanesulfonic anhydride (CH3SO2)2O or methanesulfonyl chloride (mesyl chloride, CH3SO2Cl)? Can these reagents oxidize any side-chain protecting groups (PGs) or other groups during the final mesylation reaction?

My sequence is: Ms-FRQRFH.

Thank you in advance.