I want to perform a systematic review and meta analysis of case series studies. How do I analyse these studies? There are various studies- some have subgroups, but some have only one group with pre intervention and post intervention change reported. Please help.
Sébastien Buczinski
I think it is challenging to "pool" results from case-series because of the high risk of bias of this study design. A systematic review would be the first step with an a priori idea of quality indicators of case series.
Then "pooling" should be a priori discussed based on its feasibility and clinical meaning of the different studies you gathered. Pooling poor quality studies together at any price will not give any added value vs a qualitative systematic review.
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