Dear Kishore Mallela,
Aromatic amino acid Tyrosine will involve in variety of biological process, it was repeat present in many bio proteins and enzymes and viruses, it's function give verity of applications,
Trp, have polar side chain with aromatic ring will play a key role in peptide drug development, by using this some drug host, antagonist function change give good response in medicinal chemistry.,
Phe etc also present in so many biological functions,
Almost all amino acids have specific own functions in peptides/proteins, 20essential amino acids have it's own identity have function in biological system, single amino acid not have function but its combination will yields peptides proteins,
Aromatic favor peptides and aromatic peptide will dissolve in TFA, Methanol, Ethanol, Acetonitrile, even with water, almost all type of peptide will dissolve in those solvents, peptide solubility only depends on hydrophobicity/hydrophilicity, hydrophilic favored means readily soluble in water, hydrophobic favor means TFA, etc., in peptide solubility not depends on Aromaticity.,
You may find each amino acids applications from internet sources, try to look Amino Acid journal by Springer.,
Hope You Got
Good Luck & Regards
R.Selva.........
Dear Kishore Mallela,
Aromatic amino acid Tyrosine will involve in variety of biological process, it was repeat present in many bio proteins and enzymes and viruses, it's function give verity of applications,
Trp, have polar side chain with aromatic ring will play a key role in peptide drug development, by using this some drug host, antagonist function change give good response in medicinal chemistry.,
Phe etc also present in so many biological functions,
Almost all amino acids have specific own functions in peptides/proteins, 20essential amino acids have it's own identity have function in biological system, single amino acid not have function but its combination will yields peptides proteins,
Aromatic favor peptides and aromatic peptide will dissolve in TFA, Methanol, Ethanol, Acetonitrile, even with water, almost all type of peptide will dissolve in those solvents, peptide solubility only depends on hydrophobicity/hydrophilicity, hydrophilic favored means readily soluble in water, hydrophobic favor means TFA, etc., in peptide solubility not depends on Aromaticity.,
You may find each amino acids applications from internet sources, try to look Amino Acid journal by Springer.,
Hope You Got
Good Luck & Regards
R.Selva.........
Above answer will give info regarding to your question, in addition the aromatic amino acids in protein sequence used as a one of the reverse binding active site and it alter the peptide confirmations and it give the evidence for cyclic peptide.,
Peptide solubility not depends on aromaticity,
I suggest to get involved with Amos Smith wrk as he synthesized some of the aromatic peptides. He may help in giving a clue.
Dissolve the lyophilised peptide in a small volume of DMSO. Then drop this concentrated peptide solution slowly under stirring into the desired buffer to reach the desired concentration.
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