To determine the molecular weight of Saccharomyces cerevisiae, you are supposed to take into consideration the different cellular chemical composition under certain growth conditions. For instance Schulze (1995) summarizes it to include the attachment below. You could use this for your determinations.
Dear Amaldo Firjarahadi Tane thank you for your interesting technical question. In addition to the valuable answer and link provided by Maurice Ekpenyong please also have a look at the following potentially useful articles entitled
Determination of the molecular weight of Saccharomyces cerevisiae nuclear DNA
Article Determination of the molecular weight of Saccharomyces cerev...
and
A re-evaluation of the molecular weight of yeast (Saccharomyces cerevisiae) fructose-1,6-bisphosphatase
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I agree with Phil Gays. This approach greatly dilutes the term molecular weight. Moreover, when characterizing polymer molecules, one speaks not about "Molecular weight", but about "Molecular weight distribution".