How to detect or measure drug compounds in beta cyclodextrin inclusion complex?

Souptik Bhattacharya @Souptik-Bhattacharya

14 September 2019 1 8K Report

What is the analytical method and instrument required to detect the drug which formed inclusion complex with beta cyclodextrin? How can it be detected?

Hanan Azzam

There are many analytical techniques to determine the CD-drug complex qualitatively and quantitatively for example

UV-spectroscopy and HPLC to detect dissolution constant and for loading and release study

Infra red technique (IR)

DSC ,SEM techniques

You will see different techniques in leatreature review..

Badges
Science topic

More Souptik Bhattacharya's questions See All

For the process of preparing decellularized matrices what is the ideal solution in which we can bring the tissue from slaughter house to lab?

I am planning to prepare a decellularized porcine tissue derived biomaterial. It would be very helpful if I get to know the composition of the solution which is ideal to bring the tissue sample...

31 July 2024 5,645 2 View

Does the mol. wt. of a tackifying resin affect on tackiness of a Adhesive ? If yes how ?

Effect of tackifying resin mol. wt. on tackiness of a Adhesive

21 June 2024 4,596 1 View

Difference between Radial and Linear SEBS ?

Difference between Radial and Linear SEBS, in view of processing and properties.

21 June 2024 2,927 0 View

Measuring fluorescence intensity in ImageJ?

Hello, I have a question regarding fluorescence intensity measurement in imageJ software. The tutorials provide different methods, the simplest one is to use a fixed ROI and measure the mean gray...

20 February 2024 752 0 View

How can polystyrene beads be added as a suspension in culture media?

I am trying to dissolve the PS beads in MS media as a treatment to plants. I can not make a suspension. I also require to measure Zeta potential of the PS beads, but the DLS analysis needs a...

04 February 2024 5,098 11 View

Elispot vs cultured Elispot?

Hi , My over all experimental goal is to define Zika virus-specific T cell responses in macaques infected with Zika virus. We also have control macaques that were not infected with Zika. We used...

16 November 2023 5,546 0 View

What is the treatment of choice for shoulder pain ?

It is very evident so far that although there are multiple conservative treatment for shoulder pain starting from medication to intraarticular injections to physiotherapy or naturopathy but none...

14 September 2023 6,588 7 View

What is the effect of di-block content (sis) on tackiness of a holt-melt adhesive?

What is the effect of di-block content (sis) on tackiness of a holt-melt adhesive....effect of viscosity and mol. wt. on tackiness & rheology

12 August 2023 6,351 0 View

Approximately how much time does it take for UV radiation to cause mutation in DNA?

Can higher exposure to UV radiation of my gel which I need to cut and purify create mutations for further use?

06 August 2023 7,620 0 View

Why is there a significant difference between IC50 in enzymatic assay and KD of ITC?

When checked in enzymatic assay, a compound with IC50 37 nM showed a KD value of 20 µM against ITC. How can this discrepancy be explained?

17 July 2023 3,515 1 View

Baseline drift in HPLC? What causes this?

Hello, Why do i see this baseline drift when i compare my blank (black) to the sample (blue)? Any suggestions as to why this happened? Thank you!

11 August 2024 3,770 4 View

How to calculate CCS for Sodiated adduct ions and Multiply Charged Ions?

I'm currently working on calculating the collision cross section (CCS) for various ions, and I'm facing challenges when dealing with sodiated and multiply charged ions. Most of the resources I’ve...

08 August 2024 8,329 0 View

Are there any instruments for studying time similar to the way it is in space?

There are a huge number of methods for studying objects in space, according to the senses (and not only). Mechanical, thermal, optical, acoustic, electrical, magnetic, based on particle beams,...

06 August 2024 7,102 0 View

If we are using snowball sampling technique, how do we justify the true representativeness of the sample statistically? is there any statistical test?

Are there any statistical methods to justify your sampling technique using SPSS or AMOS?

05 August 2024 9,153 4 View

For an in-vitro drug release study, what molecular weight cut-off (MWCO) dialysis bag is required for a 117 kDa protein?

kindly reply me. Thanking you in advance.

05 August 2024 7,727 4 View

What are possible strategies can be used to analyze data under sequential explanatory mixed method approach?

Better ways to analyze the qualitative and quantitative data in a sequential explanatory mixed method approaches

04 August 2024 2,703 6 View

Senescence-associated beta galactosidase staining is False Positive in control group?

Hi guys If anyone is currently working on aging cells, you guys would like to give me some advice. I'm testing against biomarker (SA-beta-Gal), I encountered a false positive in the control group...

02 August 2024 6,735 1 View

Is there any Indian Company or Startups, from any universiy or IITS, which manufacture Gas Chromatography instrument , i want to make a custOmized G?

or we can collaborate

01 August 2024 6,705 2 View

Why 3 replicates for most biological assays? Is it enough to examine the data fits normal distribution?

Just bounced on me. Before statistically analysing significant difference, shouldn't we see if data fits normal distribution first? Is 3 replicates enough to testify the hypothesis of normal...

31 July 2024 8,141 13 View

Inquiry on Maximum Nucleic Acid Volume for 2.5 mL Liposome Solution?

I am currently working on a project involving liposomes and need to determine the maximum volume of siRNA that can be added to a 2.5 mL liposome solution with a total lipid concentration of 10...

30 July 2024 6,420 1 View