Hey all!!!
I am attempting to design the pharmacokinetic experiments to calculate the oral bioavaliability of the insulin-loaded nanoparticles.
Generally, the s.c. insulin (5 IU/kg) is set as the control group in many references, and the oral bioavaliability of insulin = AUC (oral)* Dose (s.c.)/AUC (s.c.)* Dose (oral).
My concern is that if a low-dose such as s.c. insulin (1 or 2IU/kg) is utilized, the oral bioavailabilty of insulin may decrease.
Which dosage of the s.c. insulin (1 IU/kg or 5 IU/kg) should we utilize when calculate the oral bioavailability of insulin?
I don't understand why you are examining oral bioavailability of sc injected insulin? Are you assaying salivary insulin levels as an indication of plasma insulin dynamics?
I do not understand what you mean by oral bioavailability after oral administration. Your formula makes sense mathmatically but I have no idea how this relates to insulin distribution in the body regardless of route of administration????
Doses of subcutaneous lente insulin that control diabetes in streptozotocin diabetic rats are between 2 and 5 IU/kg per day.
Please explain what you are trying to study and what questions you are trying to answer, perhaps I can help if I understand your study questions....
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