In drug delivery, for efficacy, the drug concentration needs to be within LEC and MSC. How can we define that concentration?
Minimum effective concentration (MEC) is the minimum plasma concentration of a drug needed to achieve sufficient drug concentration at the receptors to produce the desired pharmacologic response, if drug molecules in plasma are in equilibrium with drug molecules in the various tissues. Maximum Safe Concentration (MSC): Also called as minimum toxic concentration (MTC) It is the concentration of drug in plasma above which adverse or unwanted effects are precipitated. Concentration of drug above MSC is said to be in the toxic level.
Thank you so much Praveen Kumar .
Is there any reference paper from where we can see that how can people measure MEC and LEC in drug delivery.
As I am working in communication engineering, we don't have scope for this experiment practically except computer simulation.
minimum effective concentration: The minimum concentration of a drug in serum required to produce a desired pharmacological effect in most patients
maximum concentration The peak concentration that a drug achieves in a specified compartment after the drug has been administrated and before administration of a second dose. Cmax is the opposite of Cmin—which is the minimum (or trough) concentration that a drug achieves after dosing.
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