How to calculate the synergy Index when the measure of risk is hazard ratio?

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Joseph L Alvarez

The synergy index may be calculated using relative risk (RR), odds ratios (OR), or hazard ratios (HR) in the formula your formula.

Victor C. Kok

Hi, good day, Prof. Alvarez,

Many thanks for your eagerly awaited answer. By the way, could you be so kind to tell us how to calculate the 95% confidence interval of the SAB?

Use the SAB equation to propagate the error using the usual propagation formulae. A reasonable 95% interval is possible if the all values are normally distributed. It may be necessary to propagate with Monte Carlo simulation.

Thank you very much!