How can I calculate hepatic clearance for liposomes given only physicochemical properties (like pKa, Log D, size, etc.) and some pharmacokinetic properties/ADME properties. I don't have any microsome or hepatocyte data at all.
Hi Tanishq, Please can you contact Dr. Ganiyat Kehinde Oloyede of University of Ibadan, Ibadan may be she can provide any assistance
Not easy way... unfortunately! Physical-chemical properties are not the key drivers of liposomes clearance. Main drivers are they ability to interact with reticulo endotelial system and phagocytes. The easiest way to trap and clear liposomes for a mammalian is however the lung, the easiest way to avoid unwonted sistemic exposure... and after lung the liposome fate is almostly unknown...
Are there any correlation-based methods to at least calculate RES clearance based on size and composition?
So hepatic clearance is very minor for liposomes?
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