Is osmolality and pH important in subcutaneous injection solution?

I making a subcutaneous formulation of conc. 20mg/ml in aqueous solution with cosolvent NMP. The pH of formulation is 6.55 and osmolality is 1352 mOsm that is the formulation is hypertonic. Is it...

09 June 2019 9,509 1 View

Is there any good coupling interfaces available for ANSYS (FEM) and EDEM (DEM)?

Actually I am thinking to apply it for a bulk of non-spherical particles in a storage faciltity

21 May 2018 8,719 4 View

GROMACS and flat-bottom position restraints

Hi, I want to know whether the flat-bottom position restraints can be applied only for the pull code in umbrella sampling or it can be use for NPT or MD simulation of GROMACS (not umbrella...

23 May 2017 8,190 1 View

Does anyone have and can share a sample questionnaire for an INTERPRETIVE STRUCTURAL MODELING technique?

I need to make an analysis of the barriers to sustainability of supply chain practices using ISM. I don't exactly know the format of such a questionnaire design. If anyone knows or has a sample....

19 December 2016 1,647 2 View

Oscillator function model for eosin yellow?

19 October 2016 8,647 9 View

Can we know the doped materials surroundings voids by refinemnet the XRD using MAUD?

From the refinement by MAUd we can generate CIF file which help to get the crystallographic structure of the material. But in case of doped material how the refinement should be changed to...

22 July 2016 4,191 3 View

How can I convert distribution of interface state density in terms of voltage to energy distribution?

I use hf C-V and conductance method to determine the interface state density of MOS structures in terms of voltage. I am not able to show the distribution in terms of energy. How do i convert the...

02 April 2015 4,463 3 View

How long does it take to degrade target transcripts by siRNA?

Typically, the effect of siRNAs are assayed after 48hrs. During this period, the siRNA is expected to "keep degrading" the existing as well as newly synthesized transcripts. Now, if there is a...

16 December 2014 5,021 4 View

Do eRNAs remain attached with the template DNA or are detached and float around?

The last couple years have seen several reports of enhancer RNAs (eRNAs and similar transcripts) that aid enhancer- and activator-dependent transcription. Arguably, a chunk of 5' end of the eRNA...

26 August 2014 2,518 4 View

Is there a protein that binds DNA stoichiometrically and sequence-nonspecifically?

For some experiments, I need a control for DNA binding of proteins; and I need a protein that binds DNA sequence-nonspecifically, and, equally importantly, stoichiometrically. Does anyone know of...

21 January 2014 2,665 5 View

After a reference from Int J Body Compos Res, can any body help?

Hi, I am after the reference below, my library says it cannot obtain a copy either locally or internationally, any help appreciated! Chris Wang ZM, Heshka S, Wielopolski L, Pi-Sunyer FX, Pierson...

03 March 2021 6,193 1 View

Irradiation data for JAPAN?

Hi, Could you help me to get the latest (2019, 2020) solar resource data for a particular site in JAPAN? PV GIS and NSRDB data are not in reach to JAPAN, I'm looking for some other database for...

03 March 2021 961 3 View

How to calculate average trend in maximum annual NDVI from MODIS?

I am wanting to calculate the average trend in maximum annual NDVI in Iceland from 2010-2020 using MODIS MYD13Q1 V6. How would I do this? I have currently inserted the NDVI bands from the MODIS...

02 March 2021 752 2 View

How Relativistic effects is one reason for lanthanide contraction?

The Lanthanide contraction which is the decrease in ionic radii of the elements in the lanthanide series from atomic number 57, lanthanum, to 71, lutetium, is due to poor shielding of the 4f...

01 March 2021 2,272 4 View

What is recommended for solid domain in ANSYS FLUENT?

Should I mesh the solid domain ? or should I use wall thickness? or Shell conduction? for Heat Transfer between two fluids of a Heat Exchanger. what is recommended?

01 March 2021 9,785 3 View

Where can I find atmospheric measurement profiles (temperature, density, etc.) between 300-800 km altitude?

I am investigating thermospheric mass density profiles between 300-800 km altitude. I would like to compare the variability with other parameters, including temperature, electron content,...

01 March 2021 5,902 3 View

How can i resolve the "final solutuin is not converged" error in Comsol for my heat transfer simulation??

I have been trying to simulate heat transfer problem in Comsol 5.5 for long time but it always throw an error stating: "Failed to find a solution. Maximum number of Newton iterations...

28 February 2021 8,626 3 View

PUC19 as a transfer plasmid for lentiviral delivery?

Hello, Is it possible to use pUC19 as a transfer vector to be packed in using the second generation viral particles packaging system( pMD2.G; psPAX2 plasmids)? As far as I understand it there is...

28 February 2021 4,868 2 View

How can we simulate an hyperelastic-viscoelastic behavor with Ansys APDL?

I am working on modeling and simulation of biomecanical material behaviour, I have succeded on simulating skin using anisotropic hyperelastic material, on APDL and in our lab's finite element...

28 February 2021 552 3 View

How to find the right number of integration points in second order 3d finite elements?

I am familiar with finite element simulations and numerical schemes like the Gauss Legendre quadrature. I also know that the Gauss integration yields exact values for polynomials up to degree 2n-1...

27 February 2021 6,818 3 View