Hi all,
I am struggling to purify a series of polyesters which do not have melting points. That is to say, they do not nicely precipitate in non-solvents and instead form highly viscous gels. I have allowed these gels to form in non-solvent while in freezer, and then have successfully decanted the mixture, leaving a crude gel behind. However HNMR still reveals the presence of unreacted monomer. There are not any literature boiling points on my monomers in this series, but they must be quite high (mw = 400-600). [I have tried vacuum drying at 100 millitorr @ 80C with no luck].
Any suggestions? Thanks!
Dear Liam Reilly, try membrane dialysis at low concentration and centrifuge. My Regards
I agree with the above answer. Perform dialysis using a good solvent for your desired product using a sufficiently high molecular weight cut off membrane. Ensure that the selected membrane is compatible with the solvent you choose.
I would try chromatographic technique. I mean submitting a not very viscous solution of your polymer through column filled with an adsorbent e.g. with previously heated and dried alumina or other one.
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