How do I eliminate noise variables when using ensemble prediction methods like randomGLM in R?

The task involves predicting a binary outcome in a small data set (sample sizes of 20-70) using many (>100) variables as potential predictors. The main problem is that the number of predictors...

10 November 2015 9,194 11 View

Is it justified to fit a mathematical model to different types of data simultaneously?

For example, cells were exposed to different concentrations of a toxic chemical. Two types of data were measured: (1) the critical concentration above which no cell growth occurred, (2) for lower...

03 April 2015 5,053 24 View

How to appropriately account for errors when fitting a mathematical model to summary data which represent percentiles (e.g. median) of a histogram?

The data provided are percentiles (median, 75th and 90th) from several histograms. The number of observations comprising each histogram is known. The shape of the data distribution in each...

31 December 2014 6,905 5 View

How to estimate a sample size for a mouse study intended to compare several potential dose response shapes using Akaike information criterion?

Suppose a mouse study is being designed which aims to address the question of which dose response shape (e.g. linear, quadratic, exponential, etc) best describes the response to a particular...

04 May 2014 3,089 11 View

Is there human or animal in vivo data on reprogramming of non-tumorigenic cancer cells to cancer stem cells during cancer radiotherapy?

Some in vitro data using cancer cell lines has been published, which suggests reprogramming of non-tumorigenic cancer cells to cancer stem cells induced by ionizing radiation. Is there some...

03 April 2014 6,328 1 View

What are some software tools (preferably free) to fit mathematical models containing differential equations to experimental data?

Suppose a mathematical model consisting of a system of differential equations is constructed to describe some biological phenomena. Analytic solutions are not available - only numerical ones. Are...

03 April 2014 476 14 View

How to statistically analyze experimental data which turned out to violate the assumptions used for initial power/sample size estimation?

For example, suppose a certain method was chosen for power/sample size calculation for a future experiment, with the intent to use the same method to analyze the experimental data. But the...

31 December 2013 5,384 20 View

What are the most efficient methods for power/sample size estimation for mouse studies with longitudinal data (e.g. tumor volumes measured over time)?

Among the many available methods, which are the most efficient (i.e. require the smallest sample size for defined alpha and beta) and relatively straightforward to implement?

11 December 2013 9,901 10 View

What are some useful techniques to statistically compare exponentially distributed data?

Suppose there are several treatment groups. Within each group there are exponentially distributed data, i.e. the number of counts is proportional to exp[-A*x^B], where A and B are parameters. What...

09 October 2013 389 56 View

How to assess goodness of fit for a non-linear model?

Suppose a non-linear smooth function is fitted to some data (e.g. means and standard errors for cell survival after various radiation doses). What are some useful ways to assess goodness of fit...

08 September 2013 7,926 39 View

No title

02 March 2021 3,060 3 View

New Journal, "Integrative Psychological and Behavioral Science" -- do you not know, and have you not seen, this done before?

Question to you and THEM, the New Journal, "Integrative Psychological and Behavioral Science" -- do you not know, and have you not seen, this done before? There appears to be a core problem for...

02 March 2021 3,024 2 View

What do you know about biotechnology art?

What do you know about biotechnology art?

02 March 2021 1,653 3 View

Which is the best place in the world for the plant biotechnology research?

I am searching for a good place for the Post Doc,

02 March 2021 4,053 3 View

Could you please recommend some good journal that accept very long revie papers (approximately 6000+ words) in neurosurgery, cancer biology ?

Could you please recommend some good journal that accept very long revie papers (approximately 6000+ words) in neurosurgery, cancer biology ?

01 March 2021 8,087 3 View

Isolates of Hymenoscyphus fraxineus?

Dear Dr. Cai, my name is Simone Prospero and I work in the team of Phytopathology at the Swiss Federal Institute for Forest Snow and Landscape Research (WSL;...

01 March 2021 1,133 1 View

How to remove the residual PDMS on the silicon mold?

Incompletely cross-linked pdms are difficult to remove.

01 March 2021 798 3 View

Is CD44 degraded in lysosome together with hyaluronan after CD44 mediated endocytosis of hyaluronic acid?

Also when RHAMM binds hyaluronic acid, they get internalized, will RHAMM also be degraded? Or both CD44 and RHAMM will be transferred back to the cell membrane? Asking for breast cancer cell line...

01 March 2021 8,169 2 View

Where to find data on trees in tropical agroforestry?

Hi, I'm looking for data (mainly related to management: growth rate, canopy size, soil and climate preferences, etc.) about tropical trees used in tropical agroforestry. Have you ever heard about...

28 February 2021 7,356 8 View

The reason that the culture of white fungi Contamination with green mold(Trichoderma), the culture autoclave at121 for 15 min. What is it?

Is the period to autoclave not enough? The inoculation in a hood and flame and UV and alcohol.

27 February 2021 9,356 3 View