I'm looking for research that has begun to correlate levels of specific bacteria to a "healthy" microbiome and how to alter patient's gut flora to sustainably colonize these beneficial flora long term.
Changing the gut micribiota is not a permanent effect. We can be achieved by feeding (food) fermented food with probiotics and preparations containing probiotics. To maintenance of the effect of prebiotics can be helpful.
Very interesting. Do you know of specific papers I can reference? Thank you!
Published work on the subject is limited. My answer results from the research experience. This is a complex and difficult issue. It can help you published in Polish J of Microbiology 2011, vol. 60, no 4 329-333. The study used a probiotic strain Lactobacillus casei DN 114001 from Danone.
Thanks so much Elzbieta! Your papers are very interesting. I will be reading them to catch up!
At the following reference, there is a review about your question, you can see the original articles at the references list.
Nielsen DS, Krych Ł, Buschard K, Hansen CHF, Hansen AK. Beyond genetics. Influence of dietary factors and gut microbiota on type 1 diabetes. FEBS Letters (2014); http://dx.doi.org/10.1016/j.febslet.2014.04.010
Thanks so much Ana Maria. I am very interested in the role our microbiota has with autoimmunity. There is so much more to explore in this area.
We are working looking for diet and microbiota relationship in autoimmunity after our study: DOI:10.1038/srep03814
Ah yes I see. Determining causal relationships can be very difficult. I will read it thank you!
Prebiotics or combination of pre-pro biotics are also useful, but also have a transient effect in adults. If you want to alter permanently your best chance is to do so during the weaning process when the microflora is maturing and establishing.
Thanks Sheila. It makes sense that it is much easier to alter the flora in infants. However, I have heard of fecal microbiota transplants having long term affects in adults. I am interested if those changes are permanent, or if they are highly dependent on diet or other factors.
Andy, you may want to read the work of Dr. Gary Wu at UPenn. They have done clinical studies on diet changes and microbiome. This one may be a good start. Diet, the human gut microbiota, and IBD by Wu et al. Hope it helps. Regarding fecal transplant, changes seem to be temporary and require multiple interventions in order to maintain a healthy microbiome. It could be due to inflammation from the underlying disease affecting the composition of the current and newly introduced flora.
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