I couldn't find exact time duration when the cardiomyopathy is developed.
There is mixed data regarding the development of cardiomyopathy in the new insulin therapy era for type 1 diabetes patients. I would recommend the article: Konduracka E, Gackowski A, Rostoff P, et al. Diabetes-specific cardiomyopathy in type 1 diabetes mellitus: no evidence for its occurrence in the era of intensive insulin therapy. Eur Heart J. 2007 Oct;28(20):2465-71 (free access). However, cardiovascular risk increases in 20 years time since the diagnosis of diabetes I.
http://eurheartj.oxfordjournals.org/content/28/20/2465.abstract
thank you David Zizek. I had search many articles and couldn't get a definite answer.Do you have any data regarding animal experiments?
I don't think.it is necessary for a type 1 DM to develop a cardiomyopathy. It can happen with long term uncontrolled sugar levels
Sorry, I have little knowledge regarding studies on animal experiments in diabetes I.
is extent of fibrosis helps to show any relation between cardiomyopathy ? OR otherwise we have only option left is noninvasive or invasive instrument to find cardiomyopathy
Diabetic cardiomyopathy is defined as ventricular dysfunction that occurs independently of coronary artery disease and hypertension. Echo usually reveals diastolic dysfunction with a reduction in early diastolic filling, an increase in atrial filling, an extension of isovolumetric relaxation. There are several mechanisms involved contributing to diastolic and systolic HF (autonomic dysfunction, metabolic derangements, abnormalities in ion homeostasis (Ca), alteration in structural proteins, and interstitial fibrosis being one of them). However, there is still a lot of controversy regarding the diagnosis. In my opinion the most any clinician at the moment (with the body of evidence) can say is in patients with longterm diabetes who present with HF (on echo - without hypertension or advanced atherosclerosis) that this COULD be diabetic cardiomyopathy.
I am also attaching an excellent review article on this topic.
can we assess Any Specific biomarkers for diabetic cardiomyopathy in rats?
I appreciate David Zizek and Ali Abdil Razzaq Muhammed Noori Aldallal. The risk of cardiovascular problems increases in 15-20 years after the diabetes is diagnosed.
Hi dear
I hope this link will help you
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1783586/pdf/RevDiabeticStud-03-108.pdf
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