How important is powder size in its effect in case of Ayurvedic dry powder formulations? I want to know if there are any published references.
Article Effect of Particle Morphology on Emitted Dose of Fatty Acid-...
Article Effect of Particle Morphology on Emitted Dose of Fatty Acid-...
Particle size have significant impact on Ayurvedic churna dissolution as well as on drug absorption. Its role in dissolution rate is described starting from the Noyes–Whitney equation, the modified form by Nerst–Brunner and the cube root equation. According to these equations diffusion of solute (Particle Size) through a boundary layer around the particles is the rate limiting step in drug dissolution and as well as in absorption, thus, its depends upon the specific (external) surface area of the particles, the diffusion coefficient of the solute, the thickness of the boundary layer and the solute solubility. In relation to this, good wetting of the particle surface by the surrounding liquid and adequate particle dispersion play an essential role
Size of particle is responsible for density, compressibility and packed density apart from dissolution on usage
- Badges
- Science topic
- Similar topics
- Linguistics
- Composition Studies
- Publisher