How effectively can we remove diisopropylurea, produced as a byproduct in diisopropylcarbodiimide coupling from reaction mixture?

More Abdul Baseer's questions See All

Post evaluation of close range photogrammetry experiments ?

I am performing a simple close range photogrammetry test and comparing outcomes of photogrammetry tools such as VisualSFM, Meshroom, Colmap etc. Kindly advice, what post evaluation tests/ criteria...

13 February 2021 6,410 3 View

In your experience what is the difference between G.652D and G.655D optical fiber. In field and in lab?

In our current era there is a big confusion about the usage of G.652 and G.655 optical fiber cable. Theoretically G.655 is much better than G.652 but the operator feel that G.652 is giving almost...

11 February 2021 4,006 8 View

Various schools have emerged in the study of comparative literature. Mention the most prominent of them in a nutshell.?

Various schools have emerged in the study of comparative literature. Mention the most prominent of them in a nutshell. And he talked about one of them?

09 February 2021 1,099 8 View

Data balancing before test/train split or only training data balancing. which is correct?

While reviewing technical articles, I encounter some papers where authors have used data balancing before splitting test and train (on full data), and some only balanced training data and let the...

04 February 2021 1,446 0 View

How can we measure disease severity of a pathogen in a crop?

severity index, measuring method and procedure detailed

01 February 2021 1,160 11 View

Why can't ANSYS Mechanical APDL detect the volume of my design ?

The 1st image shows the moment when I import my design(IGES) into the Mechanical APDL. The 2nd image occurs when I wanted to Operate>Boolean>Divide Volume By Area. The design is a regular...

28 January 2021 2,962 3 View

What is role of chronopharmacology or circadian rhythms in metabolic diseases including obesity, diabetes and cardiovascular diseases?

Chronopharmacology is branch of biological science which deals with daily life, sleep and wake, day and night, feeding and fasting and other effects. we can manage many diseases including...

18 January 2021 9,045 3 View

Why there is no effective vaccine against Congo Fever (CCHFV)?

Why there is no licensed vaccine available against congo fever? Besides what should be done to make the globally recognized Congo Vaccine?

11 January 2021 4,475 4 View

Human brain is compared to hardware in a computer while mind is compared to software to computer. How far is this comparasion suitable ?

Every function of mind works in the brain. Study of divisions of mind for memory, thinking, analysis, conscious and subconscious mind is important for successful use of the mind.

10 January 2021 5,282 32 View

How to write a PHD proposal for a predefined research?

Hello everyone, I am aiming to write a PHD proposal of 1000 words. The research is described by the supervisor. That means, research questions, aim, and instruments are well defined by the...

01 January 2021 6,291 7 View

How can Gamma Ray API units be converted to CPS (counts per second)?

Oil and gas companies run gamma ray tool and take readings in API units while Gamma ray is also noted in cps, so how these units can be converted into each other?

24 February 2021 7,545 2 View

What is the most prevalent drug related problem in the developed countries?

Detecting the drug related problems is an important step in the pharmaceutical care plan

21 February 2021 5,421 3 View

Is nanotechnology part of materials science? Is it possible to obtain Pico technology and move from hypothesis to application?

Pico-scale This is three orders of magnitude smaller than a nanometer (and thus most nanotechnology) and two orders of magnitude smaller than most chemistry transformations and measurements. Pico...

18 February 2021 4,540 5 View

XRPD Quantification - Building a calibration curve of drug excipient?

I am aiming to utilise XRPD to quantify a drug excipient within a drug product and have been having a little trouble building the calibration curve to allow for this quantification up until this...

10 February 2021 6,145 3 View

Could you please suggest to me an interesting and good book about Nanotechnology?

I want to know about nanotechnology from beginning to professional. Thus I want some book in this area

01 February 2021 1,889 13 View

How Nanotechnology helps to develop various products in Agrometeorology?

Nanotechnology (NT) is one of the advanced material science with which the development in materials and improvement in electronics. NT has made it possible to miniaturizing the things to fit in...

21 January 2021 2,305 6 View

Does the initial cell number play a role in affecting the output variables like IC50, EC50, etc.in cell-based drug screening assays? If so, how?

While performing cell-based assays to assess drug toxicity or drug efficacy, how is the initial cell seeding density determined? What is the standard followed in the pharmaceutical industry while...

07 January 2021 6,983 3 View

Is it necessary to validate the control test for each FFP separately?

Hi everyone, I would like to ask if it is necessary to validate the control test (eg sub-visible particles) for each Finished Pharmaceutical Product (FPP) separately (using the same method, the...

06 January 2021 5,568 3 View

Excipients for moisture, heat and light sensitive API with poor flow properties?

I need to formulate a water dispersible tablet with an a highly potent (Dose 7mg) API which is moisture, heat and light sensitive API with poor flow properties. Please advice on the formulation,...

01 January 2021 1,284 2 View

Is Nanotechnology applicable enough to address the need of sustainable packaging?

Sustainable packaging in today's competitive economy seems a very difficult perspective to achieve due to cost consideration, except applicable possibility in few limited areas at retail...

26 December 2020 5,998 6 View

Abdul Baseer

I am working with diisopropycarbodiimide (DIC) which is soluble in organic solvents.e.g acetone and insoluble in aqueous solutions. The byproduct of DIC after crosslinking reaction/ peptide synthesis is diisoproply urea (DIU) which is also soluble in organic solvents and insoluble in water. In my case, these two compounds are coexist in acetone. I tried with HPLC but unfortunately DIC is sensitive to water and gets hydrolyzed into Diisopropyl urea inside the column during elution.

What is the recommended method to separate these two compounds

Zineb Benzait

DIC is sensitive to water and gets hydrolyzed into Diisopropyl urea?? I found an article which reported the use of DIC for amidation reaction in water Article Amidation and esterification of carboxylic acids with amines...

do you think there is something wrong?

Tianyi Zhou

If you have a kugelrohr distiller or something similiar, you can sublimate diisopropylurea at about 1-2 mbar and 110 degree celsius.