In the MAPK signaling pathway - Homo sapiens (human) (https://www.genome.jp/kegg-bin/show_pathway?map=hsa04010&show_description=show), the gene CASP3 (https://www.genome.jp/dbget-bin/www_bget?hsa:836) activates gene STK3 (https://www.genome.jp/dbget-bin/www_bget?hsa:6788+hsa:6789). How can one gene activate/repress another gene?
Basic answer to this- Gene product of one Gene alters the arrangement of transcription factor of other gene and hence repress it.
Hi Rishika,
in this website you'll find the entire pathway regarding MAPK gene and all genes that can interact with it. just take care of the rights for the picture (https://www.selleckchem.com/pharmacological_MAPK.html).
fred
If you are just talking about MAPK signalling pathways, most of the kinases works under negative feedback inhibition mechanism.
In any case, no gene can modulate another gene. The protein product (of a particular gene) or maybe miRNAs also encoded in this genetic information/region can modulate the expression of another gene. Maybe via direct (modulation of transcription factor activity, the transcription apparature itself or maybe the spliceosome) or indirect (e.g. via modulation of signaling events, kinases/phosphatases modulation activity of relevants targets etc.) events/pathways.
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